contact
how do you get the most out of applying external resources to your projects?
what type of services and resources are needed for your project?
how can the value and quality of a developed solution be assured ?
what is knowledge and experience worth if you do not share it?
what are you looking for in the partnering resource for your project?
adlast
service
Our services cover most aspects of in vivo research as well as those functions needed to develop, support and maintain an effective care and use program.
We work with our clients in many different ways to achieve their goals on either a time-limited or a longer-term contract basis. Time-limited services include consulting sessions, expert opinion, project support and project management, whereas longer-term contracts typically covers continuous management of portions of a care and use program.
Regardless of how the client would like to engage us, we work according to our documented workflow to ensure that scope, process and end product meet our client’s expectations. In the process section you can get an overview of our workflow and read more about engaging the right expert for your project.
In order to present the breadth of expertise of adlast, we hope that you will take a couple of minutes to look at some example topics within each of the categories below. It is by no means a complete list but merely examples of tasks that we from experience know that many SME’s in life sciences may find challenging solving in-house without the support of one or more external experts. Each example is given with a list of key elements, which can be combined in multiple ways to meet your specific project or task.
We also encourage you to visit our resource section with excerpts from actual projects, which hopefully can provide you with some input and additional aspects for similar projects of your own.
▲
description
Develop a health surveillance program that confidently detects the most prevalent infectious diseases in laboratory rodent colonies and meets international standards.
key elements
Housing methods, quarantine program, laboratory testing methods, animal selection and sampling, sentinel program, husbandry practices, pest control and monitoring, colony immune status, pet policy, disinfection/sterilization methods, infection emergency plan, cost, impact on research, colony management, service provider evaluation.
description
Provide veterinary care and support on a continuous basis for a biotech SME with a limited in vivo program, including managing health monitoring, train animal care personnel and performing protocol reviews.
description
Develop and support execution of a plan to recover and re-establish as fast as possible the in vivo resources following a viral infection in the research and breeding facilities while ensuring minimal impact on ongoing research.
description
Perform causal analysis following introduction into an in vivo facility of an infectious agent: identifying the source and mode of introduction, assess impact on ongoing research and estimate total associated costs.
health monitoring program
veterinary care and support
post-infection recovery
source identification of infection
description
Manage the development of an ACUP meeting the requirements set forth in the The Guide and local regulations with the goal of achieving AAALACi accreditation.
description
Assess potential impact of the construction of a new facility adjacent to an existing and fully operated animal facility and develop a plan together with architect and contractor to minimize and mitigate negative effect of construction noise and vibration on animal welfare.
description
Develop a program to ensure and document animal welfare including veterinary oversight of the in vivo activities at a SME biotech. Prepare training plan for ACT's, suggest composition of Animal Welfare Body, and develop job description for part-time veterinary support and oversight.
description
Provide support in laboratory animal medicine and welfare prior to, during and following AAALACi re-accreditation site visit.
care and use program
construction noise and vibration
animal welfare and veterinary oversight
accreditation and certification support
description
Develop and implement a performance-based program to ensure, document and continuously improve the quality of animal care.
description
Manage breeding program for new transgenic lines, existing lines in internal facilities, and lines bred at commercial breeding facility according to established volumes, deadlines and budget.
description
Prepare a program to monitor and control vermin activity, evaluate available contractors, and assess efficiency after 12 months.
description
Improve performance of existing gnotobiotic processes to reduce required resources and decrease failure rate.
quality animal care
breeding management program
pest control and monitoring
gnotobiotic process optimization
description
Provide ad hoc scientific and technical support for the establishment and execution of a microbiome research program.
description
Search commercial and non-commercial sources of conditional and constitutive KO XX genetically modified mouse lines for intestinal integrity studies. Evaluate genetic background information and available performance data.
description
Estimate financial and human resources needed to setup a microbiome research unit with a 200 isolator cage and 500 IVC cage capacity. Assess current facility for appropriate space, infrastructure and required supporting functions and services.
description
Evaluate and audit animal vendors and service providers to ensure the welfare and quality of animals and animal services sourced meet specifications and internal ethical principles.
microbiome research support
model evaluation and selection
microbiome research unit
animal vendors and service providers
medicine
►
welfare
►
caring
►
using
►
▲
description
Develop an internal audit program focused at critical processes and prior identified quality issues. Train internal auditors in process specific focus areas and downstream impacts.
description
Develop a genetic monitoring program to confidently detect breeding errors and provide data in selecting breeders for speed congenics.
description
Develop a health surveillance program that confidently detects the most prevalent infectious diseases in laboratory rodent colonies and meets international standards.
key elements
Housing methods, quarantine program, laboratory testing methods, animal selection and sampling, sentinel program, husbandry practices, pest control and monitoring, colony immune status, pet policy, disinfection/sterilization methods, infection emergency plan, cost, impact on research, colony management, service provider evaluation.
description
Assess existing gnotobiotic monitoring program with special emphasis on detection of fungal yeasts and moulds, unculturable bacteria, and sterility of supplies.
internal audit program
genetic monitoring program
health monitoring program
gnotobiotic monitoring methodologies
description
Provide ad hoc specialist support to internal and external audit programs.
description
Define a supplier audit program for critical suppliers and service providers
key elements
identify critical products and services, material and service specifications, supplier qualification program, supplier performance, quality management system, entry QC program
description
Identify internally performed tasks that could be outsourced and evaluate the potential benefit in the following areas: capacity, quality, cost, availability, criticality and strategy.
description
Perform evaluation and audits on select suppliers of critical materials and services.
audit support
supplier audit program
outsourcing solutions
supplier evaluation and audit
description
Develop and implement a performance-based program to ensure, document and continuously improve the quality of animal care.
description
Develop a program to ensure and document animal welfare including veterinary oversight of the in vivo activities at a SME biotech. Prepare training plan for ACT's, suggest composition of Oversight Body, and develop job description for part-time veterinary support and oversight.
description
Evaluate and audit animal vendors and service providers to ensure the welfare and quality of animals and animal services sourced meet specifications and internal ethical principles.
description
Manage the development of an ACUP meeting the requirements set forth in the The Guide and local regulations with the goal of achieving AAALACi accreditation.
quality animal care
animal welfare and veterinary oversight
animal vendors and service providers
care and use program
description
Provide support in laboratory animal medicine and welfare prior to, during and following AAALACi re-accreditation site visit.
description
Manage the development of an ACUP meeting the requirements set forth in the The Guide and local regulations with the goal of achieving AAALACi accreditation.
description
Assess impact of changes to laboratory animal regulations and propose solutions with impact-analysis for cost, capacity and time to maintain regulatory compliance.
description
Devise a preventive maintenance program for all equipment and structural components with the potential of impacting animal welfare and quality in the event of failure.
accreditation and certification support
care and use program
regulatory compliance
preventive maintenance program
internal
►
external
►
welfare
►
compliance
►
▲
description
Develop a plan for converting existing facility space into an isolator facility capable of housing axenic laboratory rodents
key elements
Facility layout, capacity requirements, isolator type selection, personnel experience/training requirements, supporting function evaluation, disinfection/sterilization methods, axenic derivation and/or source selection, microbial monitoring program, husbandry practices, cost, KPI definition and benchmarking.
description
Improve performance of existing gnotobiotic processes to reduce required resources and decrease failure rate.
description
For the purpose of transforming rooms in an existing in vivo facility into a small gnotobiotic facility, an evaluation of available sterilization methods is needed with focus on cost, capacity an performance.
description
Assess existing gnotobiotic monitoring program with special emphasis on detection of fungal yeasts and moulds, unculturable bacteria, and sterility of supplies.
gnotobiotic facility
gnotobiotic process optimization
sterilization methods evaluation
gnotobiotic monitoring methodologies
description
Manage breeding program for new transgenic lines, existing lines in internal facilities, and lines bred at commercial breeding facility according to established volumes, deadlines and budget.
description
Develop and support execution of a plan to recover and re-establish as fast as possible the in vivo resources following a viral infection in the research and breeding facilities while ensuring minimal impact on ongoing research.
description
Assess breeding management program, develop requirement specifications for software solution, evaluate available software solutions against requirements and develop implementation plan.
description
Identify internally performed tasks that could be outsourced and evaluate the potential benefit in the following areas: capacity, quality, cost, availability, criticality and strategy.
breeding management program
post infection recovery
colony management software
outsourcing solutions
description
Develop a KPI-based program to assess, monitor, benchmark and improve the performance of a not-for-profit in vivo research facility.
description
Assess potential impact of the construction of a new facility adjacent to an existing and fully operated animal facility and develop a plan together with architect and contractor to minimize and mitigate negative effect of construction noise and vibration on animal welfare.
description
Identify internally performed tasks that could be outsourced and evaluate the potential benefit in the following areas: capacity, quality, cost, availability, criticality and strategy.
description
Assess proposed facility design prior to planning phase of a renovation project in collaboration with facility manager, architect and contractor. Special emphasis on bioexclusion, sanitization/decontamination/sterilization and animal/personnel/equipment movement.
facility performance
construction noise and vibration
outsourcing solutions
facility design
description
Evaluate flexible film and semi-rigid isolators for a microbiome research unit planning to perform transplantation of human microbiomes into mice. Develop specification and mitigate any impact on other research programs currently conducted at the same facility.
description
Estimate financial and human resources needed to setup a microbiome research unit with a 200 isolator cage and 500 IVC cage capacity. Assess current facility for appropriate space, infrastructure and required supporting functions and services.
description
Devise a preventive maintenance program for all equipment and structural components with the potential of impacting animal welfare and quality in the event of failure.
description
Compare open-top, IVC and isolator caging with focus on efficiency, investment, operational cost and ability to provide a stable environment for studying the microbiome in mouse models.
isolator-type selection
microbiome research unit
preventive maintenance program
housing methodologies evaluation
gnotobiology
►
animals
►
facility
►
equipment
►
⊼